National Institutes of Health (NIH) Health Care System Research Collaboratory

The overall goal of the NIH Collaboratory is to strengthen the national capacity to implement cost-effective large-scale research studies that engage health care delivery organizations as research partners. The aim of the program is to provide a framework of implementation methods and best practices that will enable the participation of many health care systems in clinical research.

The program currently supports a series of clinical trial Demonstration Projects that take place at the site of care with health care delivery systems participating as full research partners. These “pragmatic” clinical trials address a range of pressing public health concerns and take place at medical centers across the country. Dr. Jarvik’s Lumbar Imaging with Reporting of Epidemiology (LIRE) Trial was funded in the first round of demonstration projects. Details about the LIRE Pragmatic Clinical Trial can be found here.

Institute of Translational Health Sciences (ITHS)

The Institute of Translational Health Sciences (ITHS) is dedicated to speeding science to clinic practice for the benefit of patients and communities throughout Washington, Wyoming, Alaska, Montana, Idaho, and beyond. ITHS promotes this translation of scientific discovery to practice by fostering innovative research, cultivating multi-disciplinary research partnerships, and ensuring a pipeline of next generation researchers through robust educational and career development programs.

More than 6,500 researchers from nearly 200 different organizations across the five-state WWAMI region have collaborated with ITHS to attract grant funding, build their research teams, develop research tools, move research projects forward, and engage with patients and the community.

Kaiser Permanente Northern California

Kaiser Permanente Northern California (KPNC), established in 1945, is one of the largest and oldest integrated health care delivery organizations in the U.S. KPNC provides care to approximately 3.97 million members. A comprehensive health care provider, KPNC owns and operates 21 hospitals and over 200 outpatient clinics.

Mayo Clinic Health System

Started in 1992, Mayo Clinic Health System is a family of clinics, hospitals and health care facilities serving over 70 communities in Iowa, Wisconsin and Minnesota. Mayo Clinic serves more than half a million patients a year and has a provider staff of more than 900 ranging from primary to highly specialized care.

Henry Ford Health System

The Henry Ford Health System (HFHS), one of the nation’s leading vertically integrated health care systems, is a Michigan non-profit corporation encompassing Metropolitan Detroit. The vast clinical resources and diversity of the populations served by HFHS make it uniquely suited for population and clinical studies. More than one million southeast Michigan residents receive health services from Henry Ford and 40% of HFHS patient visits are by persons age 50 and over.


CERTAIN is a learning healthcare system network of healthcare provider organizations participating in research studies and initiatives that are continuously evaluating healthcare delivery, generating new evidence through research, and continually learning to improve the care of patients nationwide. Headquartered in Washington state, CERTAIN is a suite of projects and programs that track quality, benchmark best practices, drive improvement, and allow all healthcare stakeholders to have their voices heard as to what is needed to improve the system.

Neiman’s Institute

The Harvey L. Neiman Health Policy Institute studies the value and role of radiology in evolving health care delivery and payment systems, including quality-based approaches to care and the impact of medical imaging on overall health care costs. Neiman Institute research provides a foundation for evidence-based imaging policy to improve patient care and bolster efficient, effective use of health care resources.

CHASE Alliance

The UW Centers for Comparative and Health Systems Effectiveness (UW CHASE Alliance) was developed to facilitate multidisciplinary, high impact comparative and systems effectiveness research and implementation. The CHASE Alliance consists of UW researchers and community partners interested in comparative effectiveness research, health disparities, health system evaluation, technology assessment, patient-centered outcomes, economic evaluation, and dissemination and translation. The mission of the UW CHASE Alliance is to provide the multidisciplinary, collaborative environment required for the successful conduct and implementation of comparative effectiveness research in today’s and tomorrow’s complex health care system.