National Institutes of Health (NIH) Health Care System Research Collaboratory

The overall goal of the NIH Collaboratory is to strengthen the national capacity to implement cost-effective large-scale research studies that engage health care delivery organizations as research partners. The aim of the program is to provide a framework of implementation methods and best practices that will enable the participation of many health care systems in clinical research.

The program currently supports a series of clinical trial Demonstration Projects that take place at the site of care with health care delivery systems participating as full research partners. These “pragmatic” clinical trials address a range of pressing public health concerns and take place at medical centers across the country. Dr. Jarvik’s Lumbar Imaging with Reporting of Epidemiology (LIRE) Trial was funded in the first round of demonstration projects. Details about the LIRE Pragmatic Clinical Trial can be found here.

Institute of Translational Health Sciences (ITHS)

The Institute of Translational Health Sciences (ITHS) is dedicated to speeding science to clinic practice for the benefit of patients and communities throughout Washington, Wyoming, Alaska, Montana, Idaho, and beyond. ITHS promotes this translation of scientific discovery to practice by fostering innovative research, cultivating multi-disciplinary research partnerships, and ensuring a pipeline of next generation researchers through robust educational and career development programs.

More than 6,500 researchers from nearly 200 different organizations across the five-state WWAMI region have collaborated with ITHS to attract grant funding, build their research teams, develop research tools, move research projects forward, and engage with patients and the community.

Kaiser Permanente Northern California

Kaiser Permanente Northern California (KPNC), established in 1945, is one of the largest and oldest integrated health care delivery organizations in the U.S. KPNC provides care to approximately 3.97 million members. A comprehensive health care provider, KPNC owns and operates 21 hospitals and over 200 outpatient clinics.

Mayo Clinic Health System

Started in 1992, Mayo Clinic Health System is a family of clinics, hospitals and health care facilities serving over 70 communities in Iowa, Wisconsin and Minnesota. Mayo Clinic serves more than half a million patients a year and has a provider staff of more than 900 ranging from primary to highly specialized care.

Henry Ford Health System

The Henry Ford Health System (HFHS), one of the nation’s leading vertically integrated health care systems, is a Michigan non-profit corporation encompassing Metropolitan Detroit. The vast clinical resources and diversity of the populations served by HFHS make it uniquely suited for population and clinical studies. More than one million southeast Michigan residents receive health services from Henry Ford and 40% of HFHS patient visits are by persons age 50 and over.

Kaiser Permanente Washington

In 2017, Kaiser Permanente acquired Group Health Cooperative and its subsidiaries, which have been caring for members in Washington since 1947. The now-named Kaiser Permanente Washington serves more than 710,170 members and supports the health of communities in Northwest Washington, Central Washington, Eastern Washington, the Coastal and Olympic region, and Puget Sound.

Neiman’s Institute

The Harvey L. Neiman Health Policy Institute studies the value and role of radiology in evolving health care delivery and payment systems, including quality-based approaches to care and the impact of medical imaging on overall health care costs. Neiman Institute research provides a foundation for evidence-based imaging policy to improve patient care and bolster efficient, effective use of health care resources.


CERTAIN is a learning healthcare system network of healthcare provider organizations participating in research studies and initiatives that are continuously evaluating healthcare delivery, generating new evidence through research, and continually learning to improve the care of patients nationwide. Headquartered in Washington state, CERTAIN is a suite of projects and programs that track quality, benchmark best practices, drive improvement, and allow all healthcare stakeholders to have their voices heard as to what is needed to improve the system.